davidgillon | Everything's Borked

TLDR: hypermobile Ehlers Danlos Syndrome, with known immune system crossovers, turns out to have weird immune system proteins on top of all the other weirdness.

Interesting new hEDS paper I saw mentioned on FB today,

"Proteomic analysis revealed 35 differentially expressed proteins in hEDS, with 43% involved in the complement cascade and 80% linked to immune, coagulation, or inflammatory pathways. ... Cytokine profiling revealed alterations in nodal immune cell mediators in hEDS patients, supporting a model of dysregulated inflammatory response. Our findings indicate a systemic immune dysregulation, particularly involving the complement system and profibrotic cytokines, as a common feature in hEDS pathophysiology."

https://academic.oup.com/immunohorizons/article/9/10/vlaf044/8256436

The EDS Society write-up says there's another paper in the works from another team with similar results from a larger sample, and that includes people with HSD diagnoses, not just hEDS (unsurprisingly, I'm convinced the hEDS/HSD divide is bad science).

https://www.ehlers-danlos.com/exciting-new-research-sheds-light-on-heds-biology/